Prolactin Receptor

Definition 1

The Prolactin Receptor binds prolactin, initiating the cellular response to the hormone. The receptor is found in breast, placenta, liver, testes, kidneys, ovaries, and other organs. The prolactin receptor is homologous to members of the cytokine receptor superfamily, such as GHR, IL2R, IL3R, IL4R, IL6R, IL7R, EPOR, and GMCSFR. PRLR isoforms differ in the length of their cytoplasmic domains. The short form acts as a dominant-negative inhibitor, forming inactive heterodimers that inhibit Janus kinase 2 activation. (from OMIM 176761 and NCI) (NCI Thesaurus)

Definition 2

Labile proteins on or in prolactin-sensitive cells that bind prolactin initiating the cells' physiological response to that hormone. Mammary casein synthesis is one of the responses. The receptors are also found in placenta, liver, testes, kidneys, ovaries, and other organs and bind and respond to certain other hormones and their analogs and antagonists. This receptor is related to the growth hormone receptor. (NLM, Medical Subject Headings)

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