Promegapoietin

Pronunciation

Definition 1

A drug given during chemotherapy to increase blood cell regeneration. Promegapoietin is a colony-stimulating factor that stimulates the production of blood cells, especially platelets. It is a cytokine and belongs to the family of drugs called hematopoietic (blood-forming) agents. (NCI Dictionary)

Definition 2

Any one of the family of genetically engineered chimeric molecules with strong activity in promoting megakaryocyte development. Promegapoietin consists of a truncated or modified interleukin-3 (IL-3) peptide, via a hinge peptide sequence from IgG, linked to multiple repeats of modified thrombopoietin (c-Mpl ligand). This agent is capable of activating megakaryocyte progenitor cells into producing platelets mediated through either IL-3 receptor or Mpl receptor. (NCI Thesaurus)

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