| Health / Medical Topics |
Prostatic Intraepithelial Neoplasia of the Mouse Prostate Gland
Definition 1
Conceptually, distinguished from epithelial hyperplasia with atypia by unequivocally documented association with invasive carcinoma, such that the terms PIN/HGPIN have similar meaning/implications as in human. Thus far, such invasion has been observed primarily in SV40 early region/large T antigen containing transgenes (and possibly the BK5-IGF1 mouse). In these models, the in situ lesions CAN be distinguished morphologically from mice showing epithelial proliferation with atypia. T antigen models show much more pronounced nuclear atypia, including greater nuclear enlargement and pleomorphism, coarser chromatin, irregular nuclear contours, and higher mitotic and apoptotic rates. (NCI Thesaurus/MMHCC)
Definition 2
Epithelial proliferation with nuclear atypia, without invasion. Proliferation typically manifest as nuclear stratification. Atypia manifest as progressively severe nuclear enlargement, chromatin abnormalities, and enlarged nucleoli. (NCI Thesaurus/MMHCC)
Definition 3
Mouse PIN (mPIN) is defined histologically as proliferation of atypical epithelial cells within pre-existing glands and ducts and is still confined by the basement membrane. (NCI Thesaurus/MMHCC)
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