Library / English Dictionary

PROTEASE

Pronunciation (US):

(GB):

 I. (noun) 

Sense 1

Meaning:

Any enzyme that catalyzes the splitting of proteins into smaller peptide fractions and amino acids by a process known as proteolysis

Synonyms:

peptidase; protease; proteinase; proteolytic enzyme

Classified under:

Nouns denoting substances

Hypernyms ("protease" is a kind of...):

enzyme (any of several complex proteins that are produced by cells and act as catalysts in specific biochemical reactions)

Hyponyms (each of the following is a kind of "protease"):

caspase (any of a group of proteases that mediate apoptosis)

ACE; angiotensin-converting enzyme; angiotensin converting enzyme (proteolytic enzyme that converts angiotensin I into angiotensin II)

plasminogen activator; urokinase (protease produced in the kidney that converts plasminogen to plasmin and so initiates fibrinolysis)

renin (a proteolytic enzyme secreted by the kidneys; catalyzes the formation of angiotensin and thus affects blood pressure)

Credits

 Context examples: 

Similarly, phosphorylation of the protease caspase 9 or forkhead transcription factors by AKT block the induction of apoptosis by these factors.

(AKT Signaling Pathway, NCI Thesaurus/BIOCARTA)

ADAMTS proteins are soluble, extracellular matrix proteases.

(ADAM Type Metalloprotease Domain, NCI Thesaurus)

By virtue of these domains they have the potent for both cell adhesion and protease activities.

(ADAM Family Protein, NCI Thesaurus)

This allele, which encodes alpha-2-macroglobulin protein, plays a role in various processes as a protease inhibitor.

(A2M wt Allele, NCI Thesaurus)

Complement Stabilization inhibits conjugation, transport, oxidation, or proteolysis of complement system proteins; sequentially interacting serum proteins (some serine proteases), their receptors, and related regulatory proteins.

(Negative Regulation of Degradation of Complement, NCI Thesaurus)

Cathepsin K, a tissue-specific cysteine protease that catalyzes degradation of bone matrix proteins such as collagen I/II, elastin, and osteonectin plays an important role in osteoclast function and bone resorption.

(Odanacatib, NCI Thesaurus)

ADAMs (A Disintegrin and Metalloproteinase Domain) are membrane-anchored proteases that regulate cell behavior by proteolytically modifying the cell surface and extracellular matrix.

(ADAM Family Gene, NCI Thesaurus)

Ubiquitinated proteins are degraded by a 26S ATP-dependent protease complex, composed of a 20S catalytic proteasome and two 19S PA700 regulatory modules.

(PA700 Regulatory Module, NCI Thesaurus)

A synthetic antiviral agent that selectively binds to and inhibits human immunodeficiency virus (HIV) protease.

(Nelfinavir, NCI Thesaurus)

Pancreatic enzymes are comprised primarily of proteases, lipase and amylase that catalyze the breakdown of fats, carbohydrates and proteins during the digestion of food.

(Pancreatic enzyme, NCI Thesaurus)