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Protein Inhibitor of Activated STAT3
Widely expressed by human PIAS3 Gene, 619-aa 67-kDa Protein Inhibitor of Activated STAT3 contains a SAP domain and a MIZ-type zinc finger and specifically inhibits the DNA-binding signaling activity of activated STAT3, a latent cytoplasmic transcription factor that becomes activated by tyrosine phosphorylation in response to cytokine stimulation. PIAS3 shares 83% identity with mouse Pias3, approximately 55% identity with PIAS1 and PIASX proteins, and 39% identity with PIASY. Independent of STAT3 binding and by direct binding, PIAS3 also appears to block MITF DNA-binding and transcription activity. (NCI Thesaurus)
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