| Health / Medical Topics |
Protein Truncation Abnormality
Translation of a truncated form of a wild-type protein that originates from a mutation or mutations in the coding sequence of a gene. Genetic alterations that yield truncated protein products include frameshift mutations, nonsense mutations or splice site mutations. The activity of a truncated protein is usually reduced or abolished in comparison to the activity of the wild-type protein. (NCI Thesaurus)
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Termination of the translation process at a stop codon.
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