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PROTEOLYTIC
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I. (adjective)
Sense 1
Meaning:
Of or relating to proteolysis
Classified under:
Relational adjectives (pertainyms)
Pertainym:
proteolysis (the hydrolysis of proteins into peptides and amino acids by cleavage of their peptide bonds)
Derivation:
proteolysis (the hydrolysis of proteins into peptides and amino acids by cleavage of their peptide bonds)
Context examples:
This allele, which encodes ADAMTS-9, is involved in the proteolytic cleavage of large aggregating proteoglycans.
(ADAMTS9 wt Allele, NCI Thesaurus)
This group of proteins is characterized by a polybasic proteolytic processing site which is cleaved to produce a mature protein containing seven conserved cysteine residues.
(Bone Morphogenetic Protein 3B, NCI Thesaurus/LocusLink)
Preceded by extensive glycosylation, external proteolytic cleavage close to the plasma membrane may involve dimerization of the intracellular domain.
(Neuregulin 3, NCI Thesaurus)
Another proteolytic enzyme, enteropeptidase, is associated with the brush border of enterocytes; this enzyme catalyses the conversion of trypsinogen into trypsin which, in turn, can activate a number of other pancreatic zymogens.
(Pancreatic Proteolytic Enzymes, NCI Thesaurus)
Interaction with ligand leads to two additional proteolytic cleavages that liberate the Notch intracellular domain (NICD) from the plasma membrane.
(Notch Signaling Pathway, NCI Thesaurus/KEGG)
The precursor contains a signal peptide and 4 paired basic residues, putative proteolytic processing sites, indicating that the precursor may generate 3 peptides, including NMU located near the C terminus.
(Neuromedin U, NCI Thesaurus)
The membrane-bound form seems to be inactive and the cytoplasmic domain may regulate trafficking and proteolytic processing (by dimerization).
(Neuregulin 2, NCI Thesaurus)
A family of serine proteases that catalyze the proteolytic conversion of plasminogen to plasmin.
(Plasminogen Activator, NCI Thesaurus)
After internalization of the drug conjugate and proteolytic cleavage of the linker, MMAE binds to tubulin and inhibits its polymerization, which results in G2/M-phase growth arrest and tumor cell apoptosis.
(MUC16-targeted Antibody-Drug Conjugate DMUC5754A, NCI Thesaurus)
The caspases convey the apoptotic signal in a proteolytic cascade, with caspases cleaving and activating other caspases that then degrade other cellular targets that lead to cell death.
(Apoptosis DNA Damage Pathway, NCI Thesaurus/BIOCARTA)
