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PROTHROMBIN
| Pronunciation (US): |  | (GB): | |
I. (noun)
Sense 1
Meaning:
A protein in blood plasma that is the inactive precursor of thrombin
Synonyms:
factor II; prothrombin
Classified under:
Hypernyms ("prothrombin" is a kind of...):
clotting factor; coagulation factor (any of the factors in the blood whose actions are essential for blood coagulation)
Context examples:
This form of prothrombin is not efficiently converted to the active enzyme thrombin because it lacks gamma-carboxyglutamyl residues.
(Des-Gamma Carboxyprothrombin, NCI Thesaurus)
Antibodies directed against plasma proteins (such as beta-2-glycoprotein I, prothrombin, or annexin V) bound to anionic phospholipids.
(Lupus Anticoagulant Antibody, NCI Thesaurus)
Active thrombin is produced by the cleavage of prothrombin in the intrinsic thrombin activation pathway or the extrinsic thrombin activation pathway.
(Fibrinolysis Pathway, NCI Thesaurus/BIOCARTA)
Apixaban directly inhibits factor Xa, thereby interfering with the conversion of prothrombin to thrombin and preventing formation of cross-linked fibrin clots.
(Apixaban, NCI Thesaurus)
A ratio that represents the prothrombin time for a plasma specimen, divided by the result for a control plasma specimen, further standardized for the International Sensitivity Index of the tissue factor (thromboplastin) used in the test.
(International Normalized Ratio of Prothrombin Time, NCI Thesaurus/CDISC)
Test of the intrinsic (factors VIII, IX, XI, and XII) and common (fibrinogen, prothrombin, factors V and X) pathways of coagulation in which a mixture of plasma and phospholipid platelet substitute (e.g., crude cephalins, soybean phosphatides) is recalcified and the time required for the appearance of fibrin strands measured.
(Partial Thromboplastin Time, NLM, Medical Subject Headings)
The International Normalized Ratio of Prothrombin Time (INR) is the ratio of a patient prothrombin time to a normal (control) sample raised to the power of the International Sensitivity Index (ISI) with a range of 0.8 to 1.2 seconds.
(International Normalized Ratio of Prothrombin Time, NCI Thesaurus)
The second phase is the activation of prothrombin.
(Extrinsic Prothrombin Activation Pathway, NCI Thesaurus/BIOCARTA)
The prothrombin activator in the intrinsic pathway is very similar to the activator in the extrinsic pathway.
(Intrinsic Prothrombin Activation Pathway, NCI Thesaurus/BIOCARTA)
The prothrombin activation complex is formed by two pathways each of which results in a different form of the prothrombin activator.
(Extrinsic Prothrombin Activation Pathway, NCI Thesaurus/BIOCARTA)
