| Library / English Dictionary |
PROTO-ONCOGENE
| Pronunciation (US): |  | (GB): | |
I. (noun)
Sense 1
Meaning:
A normal gene that has the potential to become an oncogene
Classified under:
Hypernyms ("proto-oncogene" is a kind of...):
cistron; factor; gene ((genetics) a segment of DNA that is involved in producing a polypeptide chain; it can include regions preceding and following the coding DNA as well as introns between the exons; it is considered a unit of heredity)
Context examples:
N-myc proto-oncogene protein (464 aa, ~50 kDa) is encoded by the human MYCN gene.
(N-Myc Proto-Oncogene Protein, NCI Thesaurus)
Human v-abl Abelson murine leukemia viral oncogene homolog 1 (ABL1) gene, located at 9q34.1, encodes proto-oncogene tyrosine-protein kinase ABL1 protein.
(Oncogene ABL1, NCI Thesaurus)
This allele, which encodes L-myc-1 proto-oncogene protein, is involved in modulation of transcription by RNA polymerase II.
(MYCL1 wt Allele, NCI Thesaurus)
This allele, which encodes myc proto-oncogene protein, plays a role in the regulation of transcription by RNA polymerase II.
(MYC wt Allele, NCI Thesaurus)
Two ERBA proto-oncogenes located on separate chromosomes, encode ERBA alpha and ERBA beta, which are thyroid hormone receptors in the nucleus and bind DNA to activate transcription.
(Oncogene ERB A, NCI Thesaurus)
Myc proto-oncogene protein (439 aa, ~49 kDa) is encoded by the human MYC gene.
(Myc Proto-Oncogene Protein, NCI Thesaurus)
This allele, which encodes proto-oncogene tyrosine-protein kinase FER protein, is involved in signal transduction.
(FER wt Allele, NCI Thesaurus)
The proto-oncogene c-MET has been found to be over-expressed in a variety of cancers.
(Foretinib, NCI Thesaurus)
An orally bioavailable inhibitor of the proto-oncogene c-Met with potential antineoplastic activity. c-Met inhibitor AMG 337 selectively binds to c-Met, thereby disrupting c-Met signal transduction pathways.
(c-Met Inhibitor AMG 337, NCI Thesaurus)
Activation of G-protein proto-oncogenes via mutation results in G-protein oncogenes.
(Oncogenes, G-Proteins, NCI Thesaurus)
