| Health / Medical Topics |
Proto-Oncogene FRAT1 Protein
Encoded as same the isoform by two alternative transcripts of human FRAT1 Gene (GSK-3-Binding Protein Family), 279-aa 29-kDa Proto-Oncogene FRAT1 Protein is 79% identical to mouse Frat1, contains 3 conserved regions, and appears to participate in the WNT signaling pathway. FRAT1 binds DVL1. FRAT1 may bind GSK-3, preventing GSK-3-dependent phosphorylations and may inhibit beta-catenin phosphorylation, preventing its degradation by the ubiquitin-proteasome pathway. GBP, FRAT1, and FRAT2 contain similar sequences. GSK3-binding and -inhibitory activities of FRAT2 reside in the conserved C-terminal domain III. FRAT1 may play a role in tumor progression and lymphomagenesis with PIM1 and MYC. (NCI Thesaurus)
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