| Health / Medical Topics |
PTCH1 wt Allele
Human PTCH1 wild-type allele is located in the vicinity of 9q22.3 and is approximately 65 kb in length. This allele, which encodes protein patched homolog 1 protein, plays a role in embryonic structure formation and tumor suppression. Mutations of the gene have been associated with several cancers and disease phenotypes, including: nevoid basal cell carcinoma syndrome, esophageal squamous cell carcinoma, trichoepitheliomas, transitional cell carcinomas of the bladder, and holoprosencephaly. (NCI Thesaurus)
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