| Health / Medical Topics |
PTN wt Allele
Human PTN wild-type allele is located within 12p12.1-p11.2 and is approximately 14 kb in length. This allele, which encodes pleiotrophin protein, plays a role in mitogenesis for endothelial, epithelial, and fibroblast cells and neurite outgrowth. Further, aberrations of the gene result in allelic variants that are implicated in tumor invasion, angiogenesis, and metastasis. (NCI Thesaurus)
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