| Health / Medical Topics |
Purine-Nucleoside Phosphorylase Deficiency
PNP reversibly catalyzes the phosphorolysis of the purine nucleosides, (deoxy)inosine and (deoxy)guanosine, to their respective purine bases and the corresponding ribose-1-phosphate. Deficiency in this enzyme is an autosomal recessive cause of combined immunodeficiency. (NCI Thesaurus)
YOU MAY ALSO LIKE
Purine Synthesis Inhibition involves interference with, or restraint of, the activities of biologic molecules or complexes involved in the enzymatic formation of…
Any substance that inhibits purine nucleoside phosphorylase, an enzyme involved in the purine salvage pathway that metabolizes adenosine into adenine, inosine into…
Purine nucleoside phosphorylase (289 aa, ~32 kDa) is encoded by the human PNP gene. This protein plays a role in purine…
An antimetabolite that affects the metabolism and utilization of purines.
One of two chemical compounds that cells use to make the building blocks of DNA and RNA. Examples of purines are…
A purified protein extract derived from the bacterium Mycobacterium tuberculosis. Intradermally-administered, PPD stimulates preprimed CD4 T cells in immunologically competent subjects previously…
