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PYROPHOSPHATE
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I. (noun)
Sense 1
Meaning:
A salt or ester of pyrophosphoric acid
Classified under:
Hypernyms ("pyrophosphate" is a kind of...):
salt (a compound formed by replacing hydrogen in an acid by a metal (or a radical that acts like a metal))
Context examples:
Presence of calcium salts, especially calcium pyrophosphate, in the cartilaginous structures of one or more joints.
(Chondrocalcinosis, NLM, Medical Subject Headings)
Alendronate sodium binds to and inhibits the activity of geranyltranstransferase (farnesyl pyrophosphate synthetase), an enzyme involved in terpenoid biosynthesis.
(Alendronate sodium, NCI Thesaurus)
Cytoplasmic Hypoxanthine Phosphoribosyltransferases (Purine/Pyrimidine Phosphoribosyltransferase Family) catalyze the conversion of 5-phosphoribosyl-1-pyrophosphate and hypoxanthine, guanine, or 6-mercaptopurine to the corresponding 5'-mononucleotides and pyrophosphate.
(Hypoxanthine Phosphoribosyltransferase, NCI Thesaurus)
Phosphoribosyl pyrophosphate (PRPP) formed from ribose-5P is an activated compound used in the biosynthesis of histidine and purine/pyrimidine nucleotides.
(Pentose Phosphate Cycle Pathway, NCI Thesaurus/KEGG)
Squalene synthase catalyzes the dimerization of farnesyl-pyrophosphate to squalene, the first step in the cholesterol biosynthetic pathway that is solely committed to the production of cholesterol.
(Lapaquistat, NCI Thesaurus)
This allele, which encodes adenine phosphoribosyltransferase protein, is involved in an AMP purine salvage reaction that recycles adenine into nucleic acids by formation of AMP from adenine and 5-phosphoribosyl-1-pyrophosphate.
(APRT wt Allele, NCI Thesaurus)
These enzymes catalyze the formation of cyclic AMP and pyrophosphate from ATP and are regulated by a family of G protein-coupled receptors, protein kinases, and calcium.
(Adenylate Cyclase, NCI Thesaurus)
In addition, this agent acts as a coupling reagent for phosphoramidate or pyrophosphate inter-nucleotide bonds in DNA duplexes.
(Cyanogen Bromide, NCI Thesaurus)
The disodium salt of a nitrogen-free bisphosphonate analog of naturally occurring pyrophosphate.
(Clodronate Disodium, NCI Thesaurus)
The binding interferes with the enzymatic dephosphorylation of the C55-isoprenyl pyrophosphate and prevents peptidoglycan synthesis, thereby inhibiting bacterial cell growth.
(Bacitracin, NCI Thesaurus)
