Health / Medical Topics

    R(+)XK469

    Definition 1

    The R-isomer of a synthetic quinoxaline phenoxypropionic acid derivative with proapoptotic and antiproliferative activities. R(+)XK469 selectively inhibits topoisomerase II-beta, blocks activation of MEK/MAPK signaling kinases, stimulates caspases, and upregulates p53-dependent proteins, including cyclins A and B1, thereby arresting cancer cells in the G2/M phase of the cell cycle. Both R(+) and S(-) isomers of this agent are cytotoxic, although the R-isomer is more potent. (NCI Thesaurus)

    Definition 2

    A substance that is being studied in the treatment of leukemia. It belongs to the family of drugs called topoisomerase inhibitors. (NCI Dictionary)




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