RAD51 Homolog C

Encoded by human RAD51C Gene (RECA Family, RAD51 Subfamily), the 376-amino acid 42 kD RAD51 Homolog C is a probable nuclear protein likely involved in meiotic recombination and repair of damaged DNA. Highest expression is observed in testis, heart muscle, spleen, and prostate. RAD51 family members are strand-transfer proteins thought involved in recombinational repair of damaged DNA and in meiotic recombination. RAD51C protein interacts strongly with RAD51B and moderately with XRCC3 DNA repair proteins, but not with itself. The RAD51C/XRCC3 complex binds single-stranded, but not duplex, DNA. (from Swiss-Prot, OMIM, and NCI) (NCI Thesaurus)

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