| Health / Medical Topics |
RAG1 wt Allele
Human RAG1 wild-type allele is located in the vicinity of 11p13 and is approximately 12 kb in length. This allele, which encodes V(D)J recombination-activating protein 1, plays a role in the mediation of immunoglobulin recombination. Mutation of the gene is associated with several hereditary immunodeficiencies. Genetic variation may be associated with the relapse of acute lymphoblastic leukemia. (NCI Thesaurus)
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