RAS Homolog Gene Family, Member I Protein

Encoded by human ARHI Gene, the 229-amino acid 26 kD RHO-Related GTP-Binding Protein RHOI (RHO Family) appears to be a tumor suppressor expressed in breast and ovarian epithelial cells, and in heart, liver, pancreas, and brain; expression is absent in breast and ovarian cancer cell lines. Growth factors decrease expression of RHOI Protein, as does WAF1 (CDKN1A). The 229 amino acid protein shares 54% amino acid homology with HRAS and 56-62% homology with RAS-related proteins, and contains a highly conserved GTP-binding domain, a putative effector domain distinct from RAS and RAP proteins, and a C-terminal membrane localization motif. (from SWISS-PROT, OMIM, and NCI) (NCI Thesaurus)

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