RAS-Related Protein MRAS

Encoded by IL9-induced, but not IL2 or IL4, human MRAS Gene (Ras GTPase Family) in brain and heart only, 208-aa 24-kDa RAS-Related Protein MRAS is a GTP-binding protein implicated in neuronal differentiation and activated by NGF, basic FGF, and guanine nucleotide exchange factor GRP, but not by EGF. Activating the MAP kinase pathway, MRAS may serve as a signal transducer to couple specific trophic factors to the MAPK cascade for cell proliferation through activation of B-Raf. (NCI Thesaurus)

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