Rebamipide

A quinolinone derivative with anti-ulcer and anti-inflammatory activities. Rebamipide induces cyclooxygenase 2 (COX2) synthesis which results in an increase in endogenous prostaglandin synthesis in the gastric mucosa. This agent also inhibits H. pylori-induced production of tumor necrosis factor (TNF) alpha and subsequent inflammation of the gastric mucosa. In addition, rebamipide scavenges oxygen-derived free radicals that potentially cause mucosal injury, and stimulates prostaglandin EP4 receptor gene expression followed by mucous secretion, thereby enhancing the gastric mucosal defense. (NCI Thesaurus)

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Reasoning

Thinking that is coherent and logical.

Reason Treatment Not Administered

The reason the treatment was not administered.

Reason for Treatment Interruption

The reason the drug or therapy was temporarily ceased.

Reason for Treatment

The reason the treatment was administered.

Reason For Procedure

A rationale for executing a plan of action.

Reason for Non-Evaluation ICSR Terminology

Terminology used in Individual Case Safety Reports to specify a reason for non-evaluation of a problematic medical product, section F3.3 of FDA…