| Health / Medical Topics |
Receptor Tyrosine Kinase Inhibitor R1530
A pyrazolobenzodiazepine small molecule with potential antiangiogenesis and antineoplastic activities. Mitosis-angiogenesis inhibitor (MAI) R1530 inhibits multiple receptor tyrosine kinases involved in angiogenesis, such as vascular endothelial growth factor receptor (VEGFR)-1, -2, -3, platelet-derived growth factor receptor (PDGFR) beta, FMS-like tyrosine kinase (Flt)-3, and fibroblast growth factor receptor (FGFR) -1, -2. In addition, this agents exhibits anti-proliferative activity by initiating mitotic arrest and inducing apoptosis. (NCI Thesaurus)
YOU MAY ALSO LIKE
A process that negatively regulates the intracellular catalytic activities that originate with the binding of a tyrosine kinase-associated transmembrane receptor with its…
Tyrosine kinase receptors (TRKs) are a family of genes encoding neurotrophin receptors that include trkA, trkB, and trkC, which are related to…
A class of membrane receptors that contain protein tyrosine kinase activity. This enzymatic activity is integral to the function of the…
Refers to the presence or absence of specific receptor molecules on the surface of a cells in a specimen.
An intercellular process that involves a cellular receptor binding to a cognate ligand and results in a specific cellular response.
Receptor Serine/Threonine Kinase Genes encode receptor proteins that each bind to specific signaling factors causing a conformational and functional change in the…
