| Health / Medical Topics |
Recombinant Adenovirus-hIFN-beta
Definition 1
A recombinant replication-defective adenovirus which encodes the gene for the cytokine human interferon-beta (IFN-beta). Once inserted into and replicating in host tumor cells, recombinant adenovirus-hIFN-beta expresses human IFN-beta, which may stimulate an antiproliferative natural killer (NK) cell response against tumor cells and induce caspase-mediated tumor cell apoptosis. (NCI Thesaurus)
Definition 2
A gene therapy agent that is being studied in the treatment of cancer. It belongs to the family of drugs called biological response modifiers. (NCI Dictionary)
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