Recombinant Interleukin-12

Definition 1

A recombinant form of the endogenous heterodimeric cytokine interleukin-12 with potential antineoplastic activity. Recombinant interleukin-12 binds to and activates its cell-surface receptor, stimulating the production of interferon-gamma (IFN) which, in turn, induces IFN-gamma-inducible protein-10 (IP-10) and so inhibits tumor angiogenesis. (NCI Thesaurus)

Definition 2

One of a group of related proteins made by leukocytes (white blood cells) and other cells in the body. Interleukin-12 is made mainly by B lymphocytes and macrophages. It causes other immune cells to make cytokines and increases the growth of T lymphocytes. It may also block the growth of new blood vessels. Interleukin-12 made in the laboratory is used as a biological response modifier to boost the immune system in cancer therapy. Interleukin-12 is a type of cytokine. (NCI Dictionary)

YOU MAY ALSO LIKE

Recombinant Interleukin-1-beta

A recombinant therapeutic agent which is chemically identical to or similar to the endogenous protein cytokine interleukin 1 (IL-1)-beta. Produced by monocytes…

Recombinant Interleukin-1-alpha

A recombinant agent which is chemically identical to or similar to the endogenous protein cytokine interleukin-1 (IL-1). The IL-1 precursor is produced…

Recombinant Interleukin-1 Receptor Antagonist

Any of the recombinant form of the naturally occurring Interleukin-1 Receptor Antagonist that blocks the biological activity of Interleukin-1 by binding to…

Recombinant Interleukin-1

A recombinant therapeutic agent which is chemically identical to or similar to the endogenous cytokine interleukin-1 (IL-1). Produced mainly by monocytes, endogenous…

Recombinant Interleukin 10

A recombinant cytokine chemically identical to or similar to interleukin-10 (IL-10) secreted by certain leukocytes with immunomodulatory activities. IL-10 is an anti-inflammatory…

Recombinant Interleukin

Formulated therapeutic analogs of one of a number of endogenous cytokine interleukins. Produced by T cells, macrophages, and other cells, interleukins…