Recombinant Oncolytic Poliovirus PVS-RIPO

A recombinant, live attenuated, nonpathogenic oncolytic virus containing the oral poliovirus Sabin type 1 in which the internal ribosomal entry site (IRES) is replaced with the IRES from human rhinovirus type 2 (HRV2), with potential antineoplastic activity. Upon intratumoral administration of recombinant oncolytic poliovirus PVS-RIPO, the poliovirus is selectively taken up by and replicates in tumor cells expressing CD155 (poliovirus receptor, PVR or NECL5) eventually causing tumor cell lysis. CD155, an oncofetal cell adhesion molecule and tumor antigen, is ectopically expressed in certain cancers, such as glioblastoma multiforme (GMB), and plays an important role in tumor cell migration, invasion, and metastasis. Due to the heterologous HRV2 IRES in this recombinant virus, PVS-RIPO only propagates in susceptible, nonneuronal cells (e.g., GBM). (NCI Thesaurus)

YOU MAY ALSO LIKE

Recombinant NY-ESO-1 Protein

A genetically engineered synthetic protein, Recombinant NY-ESO-1 Protein (Cancer-Testis Tumor Antigen Family) elicits strong humoral and cellular immune responses to NY-ESO-1-expressing cancers…

Recombinant Neurotrophins

family of polypeptide growth factors produced by peripheral target tissues as well as the nervous system, which are critical to neuronal growth,…

Recombinant Neurotrophic Factor

Recombinant form of endogenous neurotrophic factors, a family of polypeptide growth factors produced by peripheral target tissues as well as the nervous…

Recombinant Neuropoietic Cytokines

Recombinant forms of endogenous neuropoietic cytokines.

Recombinant Nerve Growth Factor

NERVE GROWTH FACTOR is the first of a series of neurotrophic factors that were found to influence the growth and differentiation of…

Recombinant Nematode Anticoagulant Protein c2

An 85-amino acid recombinant peptide derived from protein c2 of the hemophagocytic hookworm Ancylostoma caninum (a common canine parasite) with anticoagulant…