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recombinant vaccinia-TRICOM vaccine
Pronunciation
Definition 1
A cancer vaccine made with a form of a vaccinia virus that does not cause disease in humans. It is being studied in the treatment of some types of cancer. The virus is changed in the laboratory to make human proteins that may help immune cells in the body kill tumor cells. Also called rV-TRICOM and vaccinia-TRICOM vaccine. (NCI Dictionary)
Definition 2
A vaccine consisting of recombinant vaccinia virus encoding a TRIad of COstimulatory Molecules (B7-1, ICAM-1, and LFA-3; also called TRICOM). Vaccination with recombinant vaccinia-TRICOM vaccine stimulates the host immune system to mount a non-specific T-cell response. With the addition of a tumor-associated antigen peptide, this vaccine may enhance a tumor-specific immune response. (NCI Thesaurus)
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