Reparixin

An orally available inhibitor of CXC chemokine receptor types 1 (CXCR1) and 2 (CXCR2), with potential antineoplastic activity. Upon administration, reparixin allosterically binds to CXCR1 and prevents CXCR1 activation by its ligand interleukin 8 (IL-8 or CXCL8). This may cause cancer stem cell (CSC) apoptosis and may inhibit tumor cell progression and metastasis. CXCR1, overexpressed on CSCs, plays a key role in CSC survival and the ability of CSC to self-renew; it is also linked to tumor resistance to chemotherapy. Inhibition of the IL-8/CXCR1 interaction also potentiates the cytotoxic effect of chemotherapeutic agents. In addition, reparixin inhibits CXCR2 activation and may reduce both neutrophil recruitment and vascular permeability during inflammation or injury. (NCI Thesaurus)

YOU MAY ALSO LIKE

Repairosome

A liposome that contains a repair protein for use in topical lotion as therapy or prevention.

Repair Enzymology

The study of the enzymes and mechanisms involved in the repair of damaged DNA.

Repair Complex

Initial or intermediate protein-DNA complexes present during the process of DNA repair.

Repair

The act of returning something to working order.

Repaglinide

A nonsulfonylurea insulin secretagogue belonging to the melgitinide class with hypoglycemic activity. Repaglinide is rapidly absorbed and has a rapid onset and…

Repackaging

Placement of an already-marketed product from its original primary container or closure system into a new container or closure system.