| Library / English Dictionary |
RETINOBLASTOMA
| Pronunciation (US): |  | (GB): | |
I. (noun)
Sense 1
Meaning:
Malignant ocular tumor of retinal cells; usually occurs before the third year of life; composed of primitive small round retinal cells
Classified under:
Nouns denoting stable states of affairs
Hypernyms ("retinoblastoma" is a kind of...):
malignant neoplasm; malignant tumor; metastatic tumor (a tumor that is malignant and tends to spread to other parts of the body)
Context examples:
A minority of patient with bilateral retinoblastoma were found to have involvement of the pineal gland as well.
(Bilateral Retinoblastoma, NCI Thesaurus)
CDK4/6 inhibitor LEE011 specifically inhibits CDK4 and 6, thereby inhibiting retinoblastoma (Rb) protein phosphorylation.
(CDK4/6 Inhibitor LEE011, NCI Thesaurus)
RB94 is a modified, N-terminal truncated form of the full-length protein retinoblastoma gene RB110, and exerts enhanced antitumor activity.
(Liposome-encapsulated RB94 Plasmid DNA Gene Therapy Agent SGT-94, NCI Thesaurus)
The most common eye cancer in children is retinoblastoma, which starts in the cells of the retina.
(Eye Cancer, NIH)
A retinoblastoma characterized by the absence of a distinct retinal mass and the presence of malignant cells diffusely infiltrating the retina.
(Diffuse Retinoblastoma, NCI Thesaurus)
CDK4/6 inhibitor LY2835219 specifically inhibits CDK4 and 6, thereby inhibiting retinoblastoma (Rb) protein phosphorylation in early G1.
(CDK4/6 Dual Inhibitor LY2835219, NCI Thesaurus)
Palbociclib selectively inhibits cyclin-dependent kinase 4 (CDK4) and 6 (CDK6), thereby inhibiting retinoblastoma (Rb) protein phosphorylation early in the G1 phase leading to cell cycle arrest.
(Palbociclib, NCI Thesaurus)
ICOVIR-5, a virus derived from wild-type human adenovirus serotype 5 (Had5), has been modified to selectively replicate in tumor cells that have a deregulated retinoblastoma/E2F pathway.
(Oncolytic Adenovirus ICOVIR5-infected Autologous Mesenchymal Stem Cells, NCI Thesaurus)
Over half of these tumours show defects in the tumour suppressors p53 and/or the retinoblastoma protein (RB) genes and pathways, and over 50% of these tumours progress to local and distant metastases.
(Bladder Cancer Pathway, NCI Thesaurus/KEGG)
A predisposition to retinoblastoma has been associated with 13q14 cytogenetic abnormalities.
(Hereditary Retinoblastoma, NCI Thesaurus)
