Retinoid 9cUAB30

Definition 1

A synthetic analogue of 9-cis retinoic acid with potential antineoplastic and chemopreventive activities. Retinoid 9cUAB30 binds to and activates retinoid X receptor (RXR) homodimers and/or and retinoic acid receptor (RAR)/RXR heterodimers, which may result in the dissociation of corepressor protein and the recruitment of coactivator protein, followed by transcription of downstream target genes into mRNAs and protein translation. Gene transcription regulated by these transcription factors may result in inhibition of cell proliferation, induction of cell differentiation, and apoptosis of both normal cells and tumor cells. (NCI Thesaurus)

Definition 2

A substance being studied in the treatment and prevention of cancer. It blocks an enzyme that keeps cells alive by adding material to the ends of chromosomes. Blocking this enzyme may cause the cancer cells to die. 9cUAB30 is a type of retinoic acid and a type of telomerase inhibitor. (NCI Dictionary)

YOU MAY ALSO LIKE

Retinoid

Vitamin A or a vitamin A-like compound.

Retinoic Acid-Induced Protein 1

Retinoic acid-induced protein 1 (1906 aa, ~203 kDa) is encoded by the human RAI1 gene. This protein may be involved in both…

Retinoic Acid Syndrome

A syndrome observed in patients with acute promyelocytic leukemia treated with all-trans retinoic acid. It is characterized by weight gain, dyspnea, pleural…

Retinoic Acid Response Element

A cis-acting transcription regulatory element. It is bound by the retinoic acid receptors.

Retinoic Acid Receptor RXR-Gamma

Retinoic acid receptor RXR-gamma (463 aa, ~51 kDa) is encoded by the human RXRG gene. This protein is involved in the modulation…

Retinoic Acid Receptor RXR-Beta

Retinoic acid receptor RXR-beta (533 aa, ~57 kDa) is encoded by the human RXRB gene. This protein plays a role in both…