Library / English Dictionary |
REVERSIBLY
Pronunciation (US): | (GB): |
I. (adverb)
Sense 1
Meaning:
Example:
reversibly convertible
Classified under:
Domain category:
chemical science; chemistry (the science of matter; the branch of the natural sciences dealing with the composition of substances and their properties and reactions)
natural philosophy; physics (the science of matter and energy and their interactions)
Pertainym:
reversible (capable of assuming or producing either of two states)
Context examples:
Miglustat competitively and reversibly binds to and inhibits the activity of UDP-glucose ceramide glucosyltransferase, which catalyzes the initial step in the synthesis of glycosphingolipids (GSL).
(Miglustat, NCI Thesaurus)
In vivo, the active metabolite, MPA, reversibly inhibits inosine 5'-monophosphate dehydrogenase, an enzyme involved in the de novo synthesis of guanine nucleotides.
(Mycophenolate mofetil, NCI Thesaurus)
A small amount of methemoglobin is present in the blood normally, but injury or toxic agents convert a larger proportion of hemoglobin into methemoglobin, which does not function reversibly as an oxygen carrier.
(Methemoglobinemia, NLM, Medical Subject Headings)
Chromomycin A3 reversibly binds to guanine-cytosine (G-C) base pairs in the minor groove of DNA, thereby inhibiting RNA synthesis.
(Chromomycin A3, NCI Thesaurus)
Dyclonine reversibly binds to activated sodium channels on the neuronal membrane, thereby decreasing the neuronal membrane's permeability to sodium ions, leading to an increased threshold for excitation.
(Dyclonine, NCI Thesaurus)
In vivo, the active molecule MPA reversibly inhibits inosine monophosphate dehydrogenase (IMPDH) which is needed for guanine monophosphate synthesis and stops the proliferation of B and T lymphocytes.
(Mycophenolate Sodium, NCI Thesaurus)
This agent appears to specifically and reversibly inhibit immunocompetent lymphocytes in the G0-or G1-phase of the cell cycle.
(Cyclosporine, NCI Thesaurus)
Bivalirudin reversibly binds thrombin, free as well as clot bound, at the catalytic site and the anion-binding exosite, thereby preventing the formation and activation of fibrin, factor XIIIa, and other coagulation factors.
(Bivalirudin, NCI Thesaurus)
Benzocaine binds to the sodium channel and reversibly stabilizes the neuronal membrane which decreases its permeability to sodium ions.
(Benzocaine, NCI Thesaurus)
Chlorodihydropyrimidine competitively and reversibly inhibits dihydropyrimidine dehydrogenase, a rate-limiting enzyme in the catabolism of fluoropyrimidines thereby blocking the degradation of the fluoropyrimidines.
(Chlorodihydropyrimidine, NCI Thesaurus)