Reye Syndrome

Pronunciation

Definition 1

A rare disease that damages the brain and liver and causes death if not treated. It occurs most often in children younger than 15 years who have had a fever-causing virus, such as chickenpox or flu. Taking aspirin during a viral illness may increase the risk of Reye syndrome. (NCI Dictionary)

Definition 2

An acute and potentially fatal metabolic disorder characterized by cerebral edema, fatty liver and hypoglycemia. It occurs primarily in children and has been associated with the use of aspirin for the treatment of viral infections. However, it can also occur in the absence of aspirin use. (NCI Thesaurus)

Definition 3

An acute, potentially fatal metabolic disease seen primarily in children and characterized clinically by vomiting, hypoglycemia, and confusion, which may progress to coma. Pathologic features include cerebral edema and fatty infiltration of the liver and other organs. (From Adams et al., Principles of Neurology, 6th ed, p1120) (NLM, Medical Subject Headings)

More information

Reye syndrome is a rare illness that can affect the blood, liver, and brain of someone who has recently had a viral infection. It always follows another illness. Although it mostly affects children and teens, anyone can get it. It can develop quickly and without warning. It is most common during flu season. Symptoms include

• Nausea and vomiting
• Listlessness
• Personality change - such as irritability, combativeness or confusion
• Delirium
• Convulsions
• Loss of consciousness

If these symptoms occur soon after a viral illness, seek medical attention immediately. Reye syndrome can lead to a coma and brain death, so quick diagnosis and treatment are critical. Treatment focuses on preventing brain damage. There is no cure.