| Health / Medical Topics |
Rho-Associated, Coiled-Coil Containing Protein Kinase 1
Encoded by human ROCK1 Gene, Rho-Associated Coiled-Coil Containing Protein Kinase 1 is a Ser/Thr kinase activated when bound to GTP-bound Rho. The small GTPase Rho regulates formation of focal adhesions and stress fibers, as well as adhesion and aggregation of platelets and lymphocytes by shuttling between inactive GDP-bound and active GTP-bound forms. Rho is also essential in cytokinesis and plays a role in transcriptional activation by serum response factor. As a downstream effector of Rho, ROCK phosphorylates and activates LIM kinase, which phosphorylates cofilin and inhibits its actin-depolymerizing activity. (NCI Thesaurus)
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