| Health / Medical Topics |
Rho Guanine Nucleotide Exchange Factor 1
Ubiquitously expressed by human ARHGEF1 Gene as alternative isoforms 1 (912-aa, 102-kD) and 2 (879-aa), cytoplasmic Rho Guanine Nucleotide Exchange Factor 1 contains a (homooligomerizing) coiled coil region, a DH domain, a PH domain, and an RGSL domain (necessary for GAP activity). Responsive to extracellular stimuli acting through GPCRs, ARHGEF1 may complex with G proteins and regulates cell cycle and cell proliferation activity. Phosphorylated by PKCA and translocated to the plasma membrane by stimulation, ARHGEF1 seems to regulate RHOA GTPase signal transduction as a GEF and GNA12 and GNA13 (RGS domain interaction) as a GAP. ARHGEF1 GEF activity is inhibited by binding to activated GNA12. (NCI Thesaurus)
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