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Rubitecan
Definition 1
A semisynthetic agent related to camptothecin with potent antitumor and antiviral properties. Rubitecan binds to and inhibits the enzyme topoisomerase I and induces protein-linked DNA single-strand breaks, thereby blocking DNA and RNA synthesis in dividing cells; this agent also prevents repair of reversible single-strand DNA breaks. (NCI Thesaurus)
Definition 2
An alkaloid drug belonging to a class of anticancer agents called topoisomerase inhibitors. (NCI Dictionary)
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