| Health / Medical Topics |
sarCNU
Definition 1
A substance being studied in the treatment of cancer. It is a type of alkylating agent. Also called sarcosinamide nitrosourea. (NCI Dictionary)
Definition 2
An alkylating chloroethylnitrosourea with antineoplastic activity. Selectively accumulating in some tumor cells, SarCNU forms covalent linkages with nucleophilic centers in DNA, causing depurination, base pair miscoding, strand scission, and DNA-DNA cross-linking, which may result in cytotoxicity. (NCI Thesaurus)
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