| Health / Medical Topics |
Scaffold Attachment Factor B
Encoded by human SAFB Gene, HET Scaffold Attachment Factor B is a highly charged monomeric 915-amino acid scaffold attachment factor with high S/MAR (Scaffold/Matrix-Associating Region) DNA-binding specificity; scaffold attachment factors A, B, C, and D interact with S/MAR DNA. The protein contains potential phosphorylation, glycosylation, and myristylation sites. Eukaryotic interphase chromatin is organized in thousands of loop domains fixed at their base through genomic S/MAR sequences to a nuclear matrix network of protein and RNA important for chromatin compaction, gene expression, and replication. SAFB is a HSP27 promoter-binding protein that decreases HSP27 transcription as an estrogen receptor corepressor. SAFB also interacts with RNA polymerase II and serine-/arginine-rich RNA processing factors and may help to assemble a 'transcriptosome complex' near active genes. (from OMIM and NCI) (NCI Thesaurus)
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