| Health / Medical Topics |
Secreted Frizzled-Related Protein 4
Encoded by human SFRP4 Gene (SFRP Family), Secreted Frizzled-Related Protein 4 is a soluble modulator of WNT signaling that contains an N-terminal signal peptide, no transmembrane domain, a hydrophilic C terminus, and a Cys-rich domain homologous to the putative WNT-binding site of Frizzled proteins. Involved in cytoskeletal regulation, apoptosis, and proliferation, WNT-mediated simulation of 'Frizzled' receptors can activate beta-catenin, MAPK kinase, and G protein pathways. Bound to WNTs or frizzled receptors, secreted frizzled-related proteins antagonize WNT/frizzled pathways. SFRP4 may inhibit WNT8-mediated development of secondary axes. (NCI Thesaurus)
YOU MAY ALSO LIKE
Secreted frizzled-related protein 2 (295 aa, ~33 kDa) is encoded by the human SFRP2 gene. This protein is involved in regulating cell…
Secreted frizzled-related protein 1 (314 aa, ~35 kDa) is encoded by the human SFRP1 gene. This protein is involved in the modulation…
Secreted and transmembrane protein 1 (248 aa, ~27 kDa) is encoded by the human SECTM1 gene. This protein may be involved in…
To form and release a substance. In the body, cells secrete substances, such as sweat that cools the body or hormones that…
A document certifying a person to perform routine administrative, or personal tasks for a superior, including word processing, bookkeeping, file and record…
Provides secretarial and technical support to Cancer Center members including preparation of typed material, distribution of postal and electronic mail, scheduling conference/rooms/seminars,…
