Selumetinib Sulfate

The sulfate salt of selumetinib, an orally active, small molecule with potential antineoplastic activity. Selumetinib is an ATP-independent inhibitor of mitogen-activated protein kinase kinase (MEK or MAPK/ERK kinase) 1 and 2. MEK 1 and 2 are dual specificity kinases that are essential mediators in the activation of the RAS/RAF/MEK/ERK pathway, are often upregulated in various cancer cells, and are drivers of diverse cellular responses, including proliferation. Inhibition of both MEK1 and 2 by selumetinib prevents the activation of MEK1/2 dependent effector proteins and transcription factors, thereby leading to an inhibition of cellular proliferation in various cancers. (NCI Thesaurus)

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Selumetinib

An orally active, small molecule with potential antineoplastic activity. Selumetinib is an ATP-independent inhibitor of mitogen-activated protein kinase kinase (MEK or MAPK/ERK…

SELP wt Allele

Human SELE wild-type allele is located within 1q22-q25 and is approximately 41 kb in length. This allele, which encodes P-selectin protein, plays…

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This gene plays a role in cellular adhesion and mediates immune and endothelial cell interactions.

Sella Turcica Neoplasm

A benign or malignant neoplasm that occurs in sella turcica. Representative examples include craniopharyngioma and pituitary gland adenoma.

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A depression of the bone at the base of the skull where the pituitary gland is located.

SELL wt Allele

Human SELL wild-type allele is located within 1q23-q25 and is approximately 21 kb in length. This allele, which encodes L-selectin protein, is…