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Semustine
Pronunciation
Definition 1
An anticancer drug that belongs to the family of drugs called alkylating agents. (NCI Dictionary)
Definition 2
A methylated derivative of carmustine with antineoplastic activity. As an alkylating agent, semustine forms covalent linkages with nucleophilic centers in DNA, causing depurination, base-pair miscoding, strand scission, and DNA-DNA cross-linking, which may result in cytotoxicity. (NCI Thesaurus)
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