| Health / Medical Topics |
SENP1 wt Allele
Human SENP1 wild-type allele is located in the vicinity of 12q13.1 and is approximately 63 kb in length. This allele, which encodes sentrin-specific protease 1 protein, plays a role in both protein desumoylation and the positive regulation of apoptosis. A patient with infantile sacrococcygeal teratoma was found to have a balanced chromosomal translocation t(12;15)(q13;q25) which fuses this gene and the MESDC2 gene. (NCI Thesaurus)
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This gene is involved in both apoptosis regulation and protein desumoylation.
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