SHC Transforming Protein 2

Broadly expressed (highest in liver, pancreas, prostate, ovary, and brain) by human SLI Gene, 489-aa Neuronal SHC Adaptor Homolog contains a conserved N-terminal PTB domain, a CH domain, and a conserved C-terminal SH2 domain, as well as unique proline-rich motifs that may be SH3 recognition sites. SCK and NSHC mediate EGF signaling and both bind to neurotrophic receptors TRKA and TRKB. SCK appears to specifically associate with cytoplasmic c-SRC tyrosine kinase CSK (phosphorylated by SRC), which downregulates c-SRC kinase through C-terminal tyrosine phosphorylation. (NCI Thesaurus)

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