SHR, Rat Strain

Definition 1

SHR: rats develop hypertension spontaneously without exception at the age of 7-15 weeks. There is a systolic blood pressure plateau of about 200 mmHg. The genetic basis is polygenic, with at least three major genes involved (Tanase and Suzuki 1971, Yen et al 1974). There is a high incidence of cardiovascular disease (Okamoto et al 1973), but a low incidence of stroke which can be increased to about 30% with chronic stress (Yamori 1984). (NCI Thesaurus)

Definition 2

The spontaneous hypertensive rat was derived by Okamoto at the Kyoto school of medicine (1963) from a cross between an outbred Wistar Kyoto male with a significant elevation of blood pressure and a female Wistar Kyoto with elevated blood pressure. SHR rats develop hypertension spontaneously without exception at the age of 7-15 weeks with a systolic blood pressure plateau of about 200 mmHg. The genetic basis is polygenic, with at least three major genes involved (Tanase and Suzuki 1971, Yen et al 1974). (NCI Thesaurus/CDISC)

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