Health / Medical Topics

    sipuleucel-T

    Pronunciation

    Definition 1

    A drug used to treat prostate cancer that has spread. It is made from immune system cells collected from a patient with prostate cancer. The cells are treated with a protein that is made by combining a protein found on prostate cancer cells with a growth factor. When the cells are injected back into the patient, they may stimulate T cells to kill prostate cancer cells. Sipuleucel-T is a type of vaccine and a type of cellular adoptive immunotherapy. Also called APC8015 and Provenge. (NCI Dictionary)

    Definition 2

    A cell-based vaccine composed of autologous antigen-presenting peripheral blood mononuclear cells (enriched for a dendritic cell fraction) that have been exposed to a recombinant protein consisting of granulocyte-macrophage colony-stimulating factor (GM-CSF) fused to prostatic-acid phosphatase (PAP), a protein expressed by prostate cancer cells. Upon administration, the vaccine may stimulate an antitumor T-cell response against tumor cells expressing PAP. (NCI Thesaurus)




    YOU MAY ALSO LIKE

    A rare, genetic disorder that affects the endocrine glands and causes a type of thyroid cancer called medullary thyroid cancer, pheochromocytoma, and…
    A dual peroxisome proliferator-activated receptor (PPAR) alpha and gamma agonist, with hypoglycemic activity.
    A monoclonal antibody that is being studied in the treatment of certain lymphoproliferative disorders and psoriasis. Also called MEDI-507.
    Human SIPA1 wild-type allele is located in the vicinity of 11q13 and is approximately 75 kb in length. This allele, which encodes…
    This gene plays a role in signal transduction and is putatively involved in cytoskeletal remodeling.
    A condition in which some of the veins in the liver are blocked. This causes a decrease in blood flow inside the…

    © 1991-2023 The Titi Tudorancea Bulletin | Titi Tudorancea® is a Registered Trademark | Terms of use and privacy policy
    Contact