| Health / Medical Topics |
SJG-136
Definition 1
A substance that is being studied in the treatment of cancer. It belongs to the family of drugs called DNA cross-linking agents. (NCI Dictionary)
Definition 2
A pyrrolobenzodiazepine dimer with potential antineoplastic activity. SJG-136 binds to the minor groove of DNA and induces interstrand cross-links between two N-2 guanine positions, thereby inhibiting DNA replication and transcription. With a preference for binding to purine-GATC-pyrimidine sequences, SJG-136 adducts do not appear to be subject to p53-mediated DNA excision repair mechanisms. (NCI Thesaurus)
YOU MAY ALSO LIKE
A wild-type zebrafish line.
A wild-type zebrafish line.
An inbred line of *AB zebrafish. Unlike *AB, which is bred to retain polymorphisms, this subline is bred to reduce polymorphism and…
A soluble beta-D-glucan produced by the Basidiomycetes fungus, Schizophyllum commune Fries, with potential immunomodulating and antitumor activities. Although sizofiran's exact mechanism of…
A process to reduce the particle size of a material by mechanical grinding, attrition, or impact.
The physical magnitude of something.
