SMAD6 Protein

Encoded by MADH6 Gene (SMAD Family), ubiquitous (predominantly vascular endothelium) SMAD6 Protein Isoforms A (496-aa 53.5-kD) and B (235-aa) act similar to other MAD-proteins as second messengers distal to TGFBRs and contain an N-terminal DWA/MH1 domain and a C-terminal DWB/MH2 domain. An inhibitory SMAD phosphorylated by type 1 receptor kinase, SMAD6 acts as an antagonist of TGF-beta type 1 receptor signaling. A selective inhibitor of BMPs signaling; SMAD6 competes with SMAD4 for receptor-activated SMAD1. SMAD6 interacts with TGF-beta type I receptor superfamily members, SMAD1, HOXC8, and HOXC9. MADH6 and MADH7 form complexes. (from LocusLink, Swiss-Prot, OMIM, and NCI) (NCI Thesaurus)

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