Small Inducible Cytokine A11

Chemoattractant cytokines (chemokines) are important for leukocyte recruitment to inflammatory lesions. The eotaxin chemokine is a potent chemoattractant for eosinophil migration and accumulation. A high-affinity eotaxin receptor CCR3, involved in allergic inflammation, is highly expressed on eosinophils, basophils, and TH2 lymphocytes. CCR3, a GPCR, induces a calcium response in eosinophils, and also binds RANTES and monocyte chemotactic protein-3. Eotaxin also interacts with CCR2 and CCR5 receptors and thus can affect monocyte responses. In monocytes, eotaxin modifies responsiveness to the CCR2 ligand MCP1, as well as to RANTES and MIP1-beta, which bind to CCR5; eotaxin is a CCR5 agonist and a CCR2 antagonist. Eotaxin also induces endothelial cell migration and angiogenesis. (from OMIM 601156 and NCI) (NCI Thesaurus)

YOU MAY ALSO LIKE

Small Inducible Cytokine A1

A CCR8-ligand, the inflammatory CXC cytokine I-309 is a small inducible chemotactic factor produced by activated T-lymphocytes, mast cells, and monocytes that…

Small G Protein

A class of small GTP-binding regulatory proteins regulated by G protein coupled receptors that act as switches in signal transduction pathways. …

Small for Gestational Age

Refers to a fetus or infant who is smaller than expected for the age or gender, or who has a birthweight less…

Small Congenital Melanocytic Nevus

A congenital nevus of small size, with a diameter smaller than 1.5 cm. It presents as a macular, papular or plaque-like…

Small Colon

The terminal part of the colon of the horse with a reduced diameter.

Small Cleaved Follicle Center Cell

A lymphoid cell of follicular center cell origin that has an irregularly shaped nucleus with clumped chromatin, absent nucleoli, and one or…