| Health / Medical Topics |
Small Inducible Cytokine A13
Induced by IL-1 and TNF-alpha, widely expressed, and encoded by human CCL13 Gene (Intercrine Beta Family), 98-aa 11-kD (precursor) Small Inducible Cytokine A13 is a secreted chemotactic factor for monocytes, lymphocytes, basophils, and eosinophils that signals through CCR2B and CCR3 receptors and is involved in immunoregulatory and inflammatory processes. The protein can bind heparin and isoforms MCP-4, (LA)MCP-4, and (FNPQGLA)MCP-4 exist. CCL13 may be involved in atherosclerosis. (NCI Thesaurus)
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