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Small Inducible Cytokine A21
Definition 1
Secondary Lymphoid Tissue Chemokine is an endothelial CC (beta) subfamily chemokine expressed preferentially in lymph node tissue. Unlike other CC chemokines, SLC is specifically chemotactic for Th1 lymphocytes, and for dendritic cells. The ability of SLC to chemoattract both Th1 lymphocytes and dendritic cells formed the rationale to evaluate this chemokine in cancer immunotherapy. (from OMIM 602737 and NCI) (NCI Thesaurus)
Definition 2
This protein is chemotactic in vitro for thymocytes and activated T cells, but not for B cells, macrophages, or neutrophils. The cytokine encoded by this gene may also play a role in mediating homing of lymphocytes to secondary lymphoid organs. It is a high affinity functional ligand for chemokine receptor 7 (CCR7) that is expressed on T and B lymphocytes and a known receptor for another member of the cytokine family (small inducible cytokine A19). (NCI Thesaurus/LocusLink)
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