Smoothened Antagonist BMS-833923

An orally bioavailable small molecule SMO (Smoothened) inhibitor with potential antineoplastic activity. SMO inhibitor BMS-833923 inhibits the sonic hedgehog (SHH) pathway protein SMO, which may result in a suppression of the SHH signaling pathway. SMO is a G-protein coupled receptor that lies just downstream of the SHH ligand cell surface receptor Patched-1 in the SHH pathway; in the absence of ligand Patched-1 inhibits SMO and ligand binding to Patched-1 results in increased levels of SMO. The SHH signaling pathway plays an important role in cellular growth, differentiation and repair; constitutive activation of this pathway is associated with uncontrolled cellular proliferation and has been observed in a variety of cancers. (NCI Thesaurus)

YOU MAY ALSO LIKE

Smooth Muscle Tissue

Involuntary muscle tissue of the internal organs. It is composed of elongated muscle cells or fibers that are not arranged in a…

Smooth Muscle Neoplasm

A benign or malignant myomatous neoplasm arising from smooth muscle. -- 2003

Smooth Muscle Myosin Heavy Chain 11

Smooth Muscle Myosin Heavy Chain 11, encoded by the human MYH11 gene belonging to the myosin heavy chain family. This protein is…

Smooth Muscle Cell

An elongated spindle-shaped contractile cell, peculiar to an involuntary muscle, containing a single nucleus and longitudinally arranged myofibrils.

Smooth Muscle Antibody Measurement

The determination of the amount of smooth muscle antibody present in a sample.

Smooth Muscle Actin Staining Method

An immunohistochemical staining protocol for localization of actin. The antibody is specific for the alpha-smooth muscle actin present in smooth muscle…