| Health / Medical Topics |
Smoothened Homolog
Encoded by human SMO Gene (FZ/SMO GPCR Family), 787-aa 86-kDa (precursor) Smoothened Homolog is a 7-transmembrane G protein-coupled receptor containing 1 FZ domain that seems to form a complex with PTCH to transduce the SHH signal. SHH binding to the PTCH receptor appears to relieve constitutive SMO repression by PTCH and to activate target gene transcription. Sonic Hedgehog Homolog is the notochord inductive signal in ventral neural tube and somite patterning and the polarizing signal for anterior-posterior limb axis patterning. SMO defects are involved in BCC. (NCI Thesaurus)
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