| Health / Medical Topics |
Smoothened Receptor Antagonist LY294068
An orally bioavailable small molecule antagonist of the Hedgehog (Hh)-ligand cell surface receptor smoothened (Smo) with potential antineoplastic activity. Smo inhibitor LY2940680 inhibits signaling that is mediated by the Hh pathway protein Smo, which may result in a suppression of the Hh signaling pathway and may lead to the inhibition of the proliferation of tumor cells in which this pathway is abnormally activated. The Hh signaling pathway plays an important role in cellular growth, differentiation and repair; constitutive activation of this pathway is associated with uncontrolled cellular proliferation and has been observed in a variety of cancers. (NCI Thesaurus)
YOU MAY ALSO LIKE
Encoded by human SMO Gene (FZ/SMO GPCR Family), 787-aa 86-kDa (precursor) Smoothened Homolog is a 7-transmembrane G protein-coupled receptor containing 1 FZ…
An orally bioavailable small-molecule Smoothened (Smo) antagonist with potential antineoplastic activity. Smoothened antagonist LEQ506 selectively binds to the Hedgehog (Hh)-ligand cell surface…
A topical formulation of the small-molecule Smoothened (Smo) antagonist LDE225 with potential antineoplastic activity. Upon topical application, smoothened antagonist LDE225 selectively binds…
An orally bioavailable small molecule SMO (Smoothened) inhibitor with potential antineoplastic activity. SMO inhibitor BMS-833923 inhibits the sonic hedgehog (SHH) pathway protein…
Involuntary muscle tissue of the internal organs. It is composed of elongated muscle cells or fibers that are not arranged in a…
A benign or malignant myomatous neoplasm arising from smooth muscle. -- 2003
